This paper describes the main characteristics of the seismicity linked to the volcano-tectonic events recorded at Mount Etna during 2021 by the Seismic Network of the INGV - Etnean Observatory (OE). Out of a total of 2315 events recorded at Mount Etna, 1763 are the ones located. About 40% of these events belong to the 27 seismic sequences identified during the year. The most important sequence, both in terms of number of events (about a hundred) and of seismic energy release, occurred on January 24 and 25, 1.5 km east of Mt. Fontane (northeastern flank) at a depth greater than 10 km b.s.l. As regards the seismic energy alone released, two significant seismic sequences can be distinguished, both characterized by shallow events. The first one was recorded between 14 and 17 January in the...