Evolution of magmatic systems can be studied by using geochemical and isotopic data. Magmas generated in the mantle, during uprising, can change their characteristics undergoing a variety of chemical evolution processes. The coupling between the study of major and trace element, and radiogenic isotope compositions, may be useful to distinguish the effects of different processes of magma differentiation. The implementation of modern mass spectrometers since the first one designed by Nier [1940] made possible the measurement of variations in the isotopic composition of selected elements in natural materials and thus permitted the spectacular growth of Isotope Geology. Last generation mass spectrometers gave a new impulse to isotopic researches in the Earth Sciences, providing the...